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We also know that many patients with psoriasis are receiving either short-term steroid tapers or judicious long-term, low-dose prednisone for psoriatic arthritis without apparent ill effectsto their patients" "It looks like the combination of short-term and long-term steroid therapy may have a lot to offer. This is in part because of the ability of psoriasis to respond to low-dose steroids by the same mechanisms (in vitro and clinical trials) that the active ingredients of the steroid (estrogens, progesterone) do", explains Dr. John-Paul Marr, Head of Dermatology at the University of Texas Southwestern Medical Center Hospital for the Study of Dermatologic Diseases. So, is short-term steroid therapy for psoriasis right thing to try out, or is it best to stay away and give a gradual approach in combination with oral medications? Let's look at the facts first. "The short-term, low-dose steroid therapy for psoriasis can reduce itch-causing lesions by suppressing keratinocyte activity resulting in a higher levels of epidermal growth factor and reducing inflammation which may be responsible for reduced flare-ups (increased inflammation of the epidermis with more severe flares). This can help avoid the inflammation and recurrence seen following extensive treatments" This is because keratinocyte activity is enhanced the longer steroids are used, and that's exactly what most psoriasis patients in the trial were looking for: "This was a short-term, short-dose low-dose trial where short-term steroid therapy was used to treat the psoriasis. Thus, patients did not see a rise in their severity of acne, which is a well established problem with tetracyclines. This was an excellent outcome, as it was shown that both the placebo and the short-term, low-dose steroid therapy provided similar efficacy, with the short-term steroid having an edge where both drugs were equally effective." The researchers at the University of Texas Southwestern Medical Center Hospital for the Study of Dermatologic Diseases and their colleagues were able to find a placebo group receiving a different short-term steroid as well. This small study found a 20% reduction in acne-free period length compared to the short-term steroid therapy plus the placebo, which suggests that the short-term steroid therapy plus the placebo helped improve skin elasticity. The study is very encouraging and opens the door to a lot of more research on the effects of short-term steroid on psoriasis patients. But, there are several limitations to this study. For instance, the investigators were unaware of the Related Article: